According to the Hugh & Jane Boyd Caldwell history I got from the HistSoc, the only children who lived past childhood were; daughters; Elizabeth born 1812, Anna 1813, Jane 1814, Mary, 1815, Margery 1817, Harriet 1837; and sons; Isaac 1819, Bishop 1826, Reuben 1828, James R., 1835.

Note: This is six daughters and four sons of the twenty children in all that mother Mary Bloom Caldwell reportedly had.3
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An I. H. Caldwell 1828 (born or died), a William Caldwell who died Apr 12, 1828 "son of I.H. Caldwell, age 7 mos." and a Jonathan Caldwell who died Sept 10, 1850 "Son of I & H Caldwell, Age 13 yrs, was killed 9-10-1850" are all listed in this burial database for the Centre Methodist Episcopal Church Cemetery, Hyde, Clearfield, PA.716

[Could Isaac be the same and the father of these two?]